Structural classification of proteins Structure VS structure comparisons(e.g. using DALI reveal related groups of proteins Structurally-similar proteins with detectable sequence homology are assumed to be evolutionarily related Similarities between non-homologous proteins suggest convergent evolution to a favorable or useful fold A number of different groups have proposed classification schemes SCOP (by hand CATH (uSes SSAP FSSP (uses DaliStructural Classification of Proteins • Structure vs. structure comparisons (e.g. using DALI) reveal related groups of proteins • Structurally-similar proteins with detectable sequence homology are assumed to be evolutionarily related • Similarities between non-homologous proteins suggest convergent evolution to a favorable or useful fold • A number of different groups have proposed classification schemes – SCOP (by hand) – CATH (uses SSAP) – FSSP (uses Dali)