Apoptosis and Necrosis Apoptosis Necrosis Nature Physiologicalor Pathological accidental pathological; specific Stimulus Mild Strong Biochemistry Active, energy-dependent, Passive, energy-independent,no new protein synthesis protein synthesis DNA Specific degradation. Random degradation ladder(180-200 bp) Morphology Intact, shrinkage, Lysis, swelling condensation Inflammation No Y Apoptotic body Y No Gene regulation Yes NoApoptosis Necrosis Nature Physiological or pathological; specific Pathological, accidental Stimulus Mild Strong Biochemistry Active, energy-dependent, new protein synthesis Passive, energy-independent, no protein synthesis DNA Specific degradation, ladder (180-200 bp) Random degradation Morphology Intact, shrinkage, condensation Lysis, swelling Inflammation No Yes Apoptotic body Yes No Gene regulation Yes No Apoptosis and Necrosis