The 4 Major groove Patterns Are Distinct Maior Maior A-TA DA M G-C AADH TA MAD A C-G HDAA Minor Minor A-TA A G-C DA TAA A C-GA DAA D A M Major A-T T-A M A D A Minor A-T T-A A A A A G-C A A D H C-G G-C C-G Major H D A A A D A A D A Minor The 4 Major Groove Patterns Are Distinct 2