Pathophysiology. Basic pathophysiology changes: spasm of the arterioles activationdamage of endothelium ---reduced organ perfusion: Hypertension Proteinuria/Edema Pathology: hemorrhage /ischemia /necrosis/ 1. Placenta 1) premature aging of villi (2) hemorrhage () necrosis 2. Kidney ----glomerular changes (1) swelling of endothelial cells (2)the deposition of amorphous materials in cytoplasm produce enlargement (3) swelling of the glomerular capillaritiesPathophysiology : Basic pathophysiology changes : spasm of the arterioles --- activation/damage of endothelium ---reduced organ perfusion :Hypertension / Proteinuria / Edema Pathology : hemorrhage /ischemia /necrosis/ 1. Placenta : (1) premature aging of villi (2) hemorrhage (3) necrosis 2. Kidney ----glomerular changes (1) swelling of endothelial cells (2) the deposition of amorphous materials in cytoplasm produce enlargement (3) swelling of the glomerular capillarities