Intrisic Extrinsic patwa Ⅲ(TF)p athwa ⅫI Ⅻa Formation of TFⅦa、 prothrombin Ⅸ、ⅧaCa21ca2 2+ activator ⅹ1Xa+Va+Ca Prothrombin Thrombin Fibrinogen→ FibrinFormation of prothrombin activator Ⅹ→ Ⅹa Prothrombin Thrombin +Ⅴa+Ca2+ 、PL Fibrinogen Fibrin Ⅻ Ⅻa Ⅺ、 Ⅸ、Ⅷa、 Ca2+ Ⅲ（TF） TF-Ⅶa、 Ca2+ Intrisic pathway Extrisic pathway