第2期 周冰涵,严小璇,蓝文贤,等:胞嘧啶脱氨基酶 APOBECI研究进展 243 hepadnaviral genomes in non-humans in vivo [J]Journal of Molecular Biology, 2010, 400(3): 323-334 [36] GEE P, ANDO Y, KITAYAMA H, et al. APOBECI-mediated editing and attenuation of herpes simplex virus 1 DNA indicate that neurons have an antiviral role during herpes simplex encephalitis [J] Journal of Virology, 2011, 85(19) 9726-9736. [37] IKEDA T, ABD EL G K H, TOKUNAGA K, et al. Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBECI against the mobility of autonomous retrotransposons [J]. Nucleic Acids Research, 2011, 39(13): 5538-5554 [38] BISHOP K N. HOLMES R K, SHEEHY A M, et al. Cytidine deamination of retroviral DNA by diverse APOBEC proteins [J] Current biology:CB,2004,14(15):1392-1396. [39] BISHOP K N. HOLMES R K, SHEEHY A M, et al. APOBEC-mediated editing of viral RNA [J].Science(New York,N Y.),2004,305(5684):645. [40] IKEDA T, OHSUGI T, KIMURA T, et al. The antiretroviral potency of APOBECI deaminase from small animal species [J]. Nucleic Acids Research, 2008,36(21): 6859--6871 [41] WIEGAND H L, DOEHLE B P, BOGERD H P, et al.A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins [J].The EMBO Journal, 2004,23(12): 2451-2458 [42 ZHENG Y H. IRWIN D, KUROSU T, et al. Human APOBEC3F is another host factor that blocks human munodeficiency virus type I replication [J]Journal of Virology, 2004,78(11): 6073-6076 [43] BARRETT B S, GUO K, HARPER M S, et al. Reassessment of murine APOBECI as a retrovirus restriction factor in tite [J] [44] REHWINKEL J Mouse knockout models for HIV-I restriction factors [J]. Cellular and Molecular Life Sciences, 2014.71 (19):3749-3766 [45] AVESSON L, BARRY G The emerging role of RNA and DNA editing in cancer [J]. Biochimica et Biophysica Acta, 2014 1845(2):308-316. [46] SCHOLZOVA E, MALIK R, SEVCIK J, et al. RNA regulation and cancer development [J]. Cancer Letters, 2007, 246(1/2) [47] ROBERTS S A, LAWRENCE M S, KLIMCZAK L J, et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers [J]. Nature Genetics, 2013, 45(9):970-976 [48 TAKAI A TOYOSHIMA T, UEMURA M, et al. A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations [J].Oncogene, 2009,28(4): 469-478 [49] OKUYAMA S, MARUSAWA H, MATSUMOTO T, et al. Excessive activity of apolipoprotein B mRNA editing enzyme (APOBEC2) contributes to liver and lung tumorigenesis [J]. International Journal of Cancer 2012,130(6):1294-1301 [50] DING Q, CHANG C J, XIE X, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cer and predicts human hepatic metastasis [J]. The Journal of Clinical Investigation, 2011. 121(11): 4526-4536 [51] SHINOHARA M, I0 K, SHINDO K, et al. APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells [J].Scientific Reports, 2012, 2: 806. [52] ROSENBERG B R, HAMILTON C E, MWANGI MM, et al. Transcriptome-wide sequencing reveals numerous APOBECI mRNA-editing targets in transcript 3 UTRs [J]. Nature Structural& Molecular Biology, 2011. 18(2): 230-236 [53] ANANT S, MURMU N, HOUCHEN C W, et al. APOBECI protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression [J].Gastroenterology, 2004, 127(4): 1139-1149 [54] BLANC V, HENDERSON JO, NEWBERRY R D, et al. Deletion of the AU-rich RNA binding protein APOBECI reduces intestinal tumor burden in Apc(min)mice [J]. Cancer Research, 2007, 67(18):8565-8573 [55] LI W, CHENG X, CHEN H, et al. APOBECI increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats [J]. Neurochemical Research, 2013, 38(7): 1434-1445 RAYON-ESTRADA V, HARJANTO D, HAMILTON C E, et al. Epitranscriptomie profiling across cell types reveals第2期 周冰涵，严小璇，蓝文贤，等：胞嘧啶脱氨基酶APOBEC1研究进展 hepadnaviral genomes in non-humans in vivo［J］.Journal of Molecular Biology，2010，400（3）：323－334. ［36］ GEE P，ANDO Y，KITAYAMA H，et al. APOBEC1-mediated editing and attenuation of herpes simplex virus 1 DNA indicate that neurons have an antiviral role during herpes simplex encephalitis［J］.Journal of Virology，2011，85（19）： 9726－9736. ［37］ IKEDA T，ABD EL G K H，TOKUNAGA K，et al.Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons［J］.Nucleic Acids Research，2011，39（13）：5538－5554. ［38］ BISHOP K N，HOLMES R K，SHEEHY A M，et al.Cytidine deamination of retroviral DNA by diverse APOBEC proteins ［J］.Current Biology：CB，2004，14（15）：1392－1396. ［39］ BISHOP K N，HOLMES R K，SHEEHY A M，et al.APOBEC-mediated editing of viral RNA［J］.Science（New York，N. Y.），2004，305（5684）：645. ［40］ IKEDA T，OHSUGI T，KIMURA T，et al.The antiretroviral potency of APOBEC1 deaminase from small animal species ［J］.Nucleic Acids Research，2008，36（21）：6859－6871. ［41］ WIEGAND H L，DOEHLE B P，BOGERD H P，et al.A second human antiretroviral factor，APOBEC3F，is suppressed by the HIV-1 and HIV-2 Vif proteins［J］.The EMBO Journal，2004，23（12）：2451－2458. ［42］ ZHENG Y H，IRWIN D，KUROSU T，et al. Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication［J］.Journal of Virology，2004，78（11）：6073－6076. ［43］ BARRETT B S，GUO K，HARPER M S，et al.Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo ［J］.Virology，2014，468/469/470：601－608. ［44］ REHWINKEL J.Mouse knockout models for HIV-1 restriction factors［J］.Cellular and Molecular Life Sciences，2014，71 （19）：3749－3766. ［45］ AVESSON L，BARRY G.The emerging role of RNA and DNA editing in cancer［J］.Biochimica et Biophysica Acta，2014， 1845（2）：308－316. ［46］ SCHOLZOVA E，MALIK R，SEVCIK J，et al.RNA regulation and cancer development［J］.Cancer Letters，2007，246（1/2）： 12－23. ［47］ ROBERTS S A，LAWRENCE M S，KLIMCZAK L J，et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers［J］.Nature Genetics，2013，45（9）：970－976. ［48］ TAKAI A，TOYOSHIMA T，UEMURA M，et al.A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations［J］.Oncogene，2009，28（4）：469－478. ［49］ OKUYAMA S，MARUSAWA H，MATSUMOTO T，et al. Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2（APOBEC2）contributes to liver and lung tumorigenesis［J］. International Journal of Cancer， 2012，130（6）：1294－1301. ［50］ DING Q，CHANG C J，XIE X，et al.APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis［J］.The Journal of Clinical Investigation，2011，121（11）：4526－4536. ［51］ SHINOHARA M，IO K，SHINDO K，et al.APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells［J］.Scientific Reports，2012，2：806. ［52］ ROSENBERG B R，HAMILTON C E，MWANGI M M，et al.Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3’UTRs［J］.Nature Structural & Molecular Biology，2011，18（2）：230－236. ［53］ ANANT S，MURMU N，HOUCHEN C W，et al. APOBEC1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression［J］.Gastroenterology，2004，127（4）：1139－1149. ［54］ BLANC V，HENDERSON J O，NEWBERRY R D，et al.Deletion of the AU-rich RNA binding protein APOBEC1 reduces intestinal tumor burden in Apc（min）mice［J］.Cancer Research，2007，67（18）：8565－8573. ［55］ LI W，CHENG X，CHEN H，et al. APOBEC1 increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats［J］.Neurochemical Research，2013，38（7）：1434－1445. ［56］ RAYON-ESTRADA V，HARJANTO D，HAMILTON C E，et al. Epitranscriptomic profiling across cell types reveals 243