119.0 1:0 -0.05 ppm 119.5 1:0.2 120.0 1:0.5 1:1.0 120.5 121.0 12 10.2 10.0 9.8 9.6 94 Ko-250 nM Mapping Binding Contacts10.2 10.0 9.8 9.6 9.4 9.2 9.0 8.8 8.6 8.4 119.0 119.5 120.0 120.5 121.0 121.5 1:1.0 1:0.5 1:0.2 1:0 ~0.05 ppm KD ~ 250 nM Mapping Binding Contacts