Autacoid Drugs Autacoids are biological factors made in the body that act like "local hormones",have a brief duration,act near the site of synthesis (paracrine),and are not blood borne. Autacoids are regulating molecules metabolized locally. These factors can have many different biological actions.Autacoid Drugs • Autacoids are biological factors made in the body that act like “local hormones”, have a brief duration, act near the site of synthesis (paracrine), and are not blood borne. • Autacoids are regulating molecules metabolized locally. • These factors can have many different biological actions