Biological Consequences of Antibody Affinity/Avidity Neutralization of toxins Complement activation Immune elimination of antigen Virus neutralization More intense immune complex disease in animals higher levels of circulating antigen-antibody complexes more intense localization of immune complexes on basement membranes. more severe impairment of organ functionBiological Consequences of Antibody Affinity/Avidity ◼ Neutralization of toxins ◼ Complement activation ◼ Immune elimination of antigen ◼ Virus neutralization ◼ More intense immune complex disease in animals ◼ higher levels of circulating antigen-antibody complexes ◼ more intense localization of immune complexes on basement membranes. ◼ more severe impairment of organ function