High and low dose tolerance Primary immunization with Secondary immunization with different doses of antigen single optimal antigen dose 7 parimary response secondary respnse 10 0s 10 (swn henge) 105 aoue auoz-Bu asuodsa Apoqpuy 70 10 1101010310101051010 11010210310101051010 Antigen dose Antigen dose given in primary immunization High and low dose tolerance