Mild pain: non-opioid analgesics (nonsteroidal, anti-inflammatory drugs NSAIDs)+ adjuvant drugs Moderate pain weak opioids(codeine tramadol)+ non-opioid analgesics adjuvant drug Severe pain: strong opioids(morphine hydromorphone, fentanyl, methadone oxycodone)+ Non-opioid analgesics t adjuvant drugs• Mild pain: non-opioid analgesics (nonsteroidal, anti-inflammatory drugs NSAIDs) ± adjuvant drugs; • Moderate pain: weak opioids (codeine, tramadol) ± non-opioid analgesics ± adjuvant drug; • Severe pain: strong opioids (morphine, hydromorphone, fentanyl, methadone, oxycodone) ± Non-opioid analgesics ± adjuvant drugs