BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Human bone framework macromolecules aggered arrangement of tropocollagen(triple helices)maximizes interfilament ∴∵ Fig.6.11 Location of cross-links between the carboxy ICI and amino IN) terminal regions of adjacent tropocollagen filaments in collagen fibrils 回= mineralized colagen crystal microfiber -] cross-section of the microfiber glycoproteins bind collagen o exact role/organization is not yet known structural hierarchy o TEM micrograph in lamellar bone paper showing plywood structure Lecture 12-Inorganic Biomaterials 10of13BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Human bone framework macromolecules: Staggered arrangement of tropocollagen (triple helices) maximizes interfilament cross-links: ƒ glycoproteins bind collagen o exact role/organization is not yet known ƒ structural hierarchy o TEM micrograph in lamellar bone paper showing plywood structure5 Lecture 12 – Inorganic Biomaterials 10 of 13