4丙二酸酯法 1.通过酰基丙二酸酯法 COOEt COOEt COOEt H,/Pt CH2 O=N-OH C-N-OH H-C-NHCOCH3 醋酸 COOEt COOEt COOEt COOEt H-C-NHCOCH3 NC-CH=CH2 麦克尔加成碱 COOEt COOEt H/催 H30 加热 NCCH2CH2-C-NHCOCH3 -C02 COOEt H2NCH2CH2CH2CHCOOH NH21. 通过酰基丙二酸酯法 4 丙二酸酯法 COOEt CH2 + O=N-OH COOEt COOEt C=N-OH COOEt H-C-NHCOCH3 COOEt COOEt H-C-NHCOCH3 COOEt COOEt NCCH2CH2 -C-NHCOCH3 COOEt COOEt + NC-CH=CH2 H2NCH2CH2CH2CHCOOH NH2 H3 +O H2 /Pt 醋酸 麦克尔加成 碱 H2 /催 加热 -CO2