Several hypotheses of the pathogenesis of he have been proposed Theory of ammonia intoxication False neurotransmitter hypothesis Theory of amino acid imbalance Theory of GABA(gamma-aminobutyric acid) None of them is necessarily exclusive a conservative and conventional view of he is Almost certainly the etiology is multifactorial10 Theory of ammonia intoxication False neurotransmitter hypothesis Theory of amino acid imbalance Theory of GABA(gamma-aminobutyric acid) Several hypotheses of the pathogenesis of HE have been proposed: None of them is necessarily exclusive. A conservative and conventional view of HE is Almost certainly the etiology is multifactorial