The Burden of Osteoarthritis: Clinical and Quality-of-Life Issues Figure. Prevalence of Symptomatic Hand Osteoarthritis Among People 271 Years of Age in the framingham Study 1992-1993 3rd 4th 2nd 2nd 4th Thumb R MCP MCP Thumb Thumb ase Right Men(n=369) a 2nd 4th 5th 0.60.90.8 MCP (/sMCP MCP humb Thumb 5. Left Women(n = 663) Right DIP indicates distal interphalangeal: MCP, metacarpophalangeal: PIP, proximal interphalange hips--incidence data from a large health mainte- the experience of pain, not to mention their con- nance organization database showed that for every siderable sequelae. An analysis of a compilation 100,000 person-years, the incidence of knee Oa of various surveys(including NHANES If), data occurred 240 times compared with 100 times for bases(including the National Hospital discharge hand Oa and 88 for hip OA.2 Database), disease registers, and epidemiologic stud ies found that Oa was the seventh leading cause of Clinical Outcomes in OA disability in women and the twelfth leading cause The burden that befalls people with OA is in men. Among people 65 to 74 years of age, OA enormous both in terms of reduced function and was found to be the fifth largest cause of disabilit VOL 15. NO. 8 THE AMERICAI箱u3头 L E MANAGED CARE S225The Burden of Osteoarthritis: Clinical and Quality-of-Life Issues VOL. 15, No. 8 n The American Journal of Managed Care n S225 hips—incidence data from a large health mainte￾nance organization database showed that for every 100,000 person-years, the incidence of knee OA occurred 240 times compared with 100 times for hand OA and 88 for hip OA.21 Clinical Outcomes in OA The burden that befalls people with OA is enormous both in terms of reduced function and the experience of pain, not to mention their con￾siderable sequelae. An analysis of a compilation of various surveys (including NHANES III), data￾bases (including the National Hospital Discharge Database), disease registers, and epidemiologic stud￾ies found that OA was the seventh leading cause of disability in women and the twelfth leading cause in men.22 Among people 65 to 74 years of age, OA was found to be the fifth largest cause of disability, n Figure. Prevalence of Symptomatic Hand Osteoarthritis Among People >71 Years of Age in the Framingham Study 1992-1993 Left Right Left Right Men (n = 369) Women (n = 663) DIP DIP DIP DIP PIP PIP MCP MCP MCP MCP Thumb base Thumb base Thumb base Thumb base Thumb Thumb 2nd 2nd 3rd 3rd 4th 4th 5th 5th DIP DIP DIP DIP PIP PIP MCP MCP MCP MCP Thumb Thumb 2nd 2nd 3rd 3rd 4th 4th 5th 5th 8.8 7.3 9.3 0.6 0.9 7.3 9.9 10.4 7.4 0.8 7.4 1.5 5.0 7.1 0.3 2.5 1.6 3.0 0.0 0.3 3.6 3.8 4.1 3.0 0.0 4.4 3.3 2.7 2.7 2.7 0.0 0.0 0.3 2.2 2.5 2.2 2.5 4.1 0.5 2.7 11.9 11.9 8.9 8.5 1.1 0.3 0.5 1.7 5.1 6.5 8.0 6.0 9.6 1.1 7.5 1.9 0.0 3.0 2.8 0.0 DIP indicates distal interphalangeal; MCP, metacarpophalangeal; PIP, proximal interphalangeal. 第 134 页