3. Pharmacodynamic Effects of NsaiDs antipyretic compared with chlorpromazine NSAIDS Chlorpromazine Effects Inhibit PGs synthesis Inhibit thermotaxis center in and enhance hypothalamus. The body thermolysis temperature change according to the environment. Clinical usage Lower the abnormal artificial hibernation high temperature to Hypothermic anesthesia, normal. Used for various fever Side effects Gl reactions, no addiction Extrapyramidal effectsantipyretic : compared with chlorpromazine NSAIDs Chlorpromazine Effects Clinical usage Side effects GI reactions，no addiction Lower the abnormal high temperature to normal. Used for various fever. artificial hibernation, Hypothermic anesthesia, Extrapyramidal effects Inhibit PGs synthesis and enhance thermolysis Inhibit thermotaxic center in hypothalamus. The body temperature change according to the environment. 3. Pharmacodynamic Effects of NSAIDs