Reissner's membrane Stria vascularis Ko vestibuli +80mv Endo- lv mpl -45 mV tympani 0 mV Depolarization Perilymph media Inner hair cell (②) Potential difference between endolymph and Vesicles inner hair cell cytoplasm= 125 mV Opening of transduction channels leads to a positively- Transmitter charged transduction current influx (largely K) that opens Afferent baso-lateral Ca**+ channels, depolarizing the hair cell and nerve To brain leads to release of neurotransmitters at hair cell basePotential difference between endolymph and inner hair cell cytoplasm = 125 mV Opening of transduction channels leads to a positively- charged transduction current influx (largely K+) that opens baso-lateral Ca++ channels, depolarizing the hair cell and leads to release of neurotransmitters at hair cell base