Journal of Medicinal Chemistry Subscriber access provided by WEIZMANN INSTITUTE Article The Crystal Structure of a Complex of Acety cholinesterase with a Bis-)- nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad Aviv Paz, Qiong Xie, Harry M. Greenblatt, Wei Fu, Yun Tang, Israel Silman, Zhuibai Qiu, and Joel L. Sus J Med. Chem., 2009, 52 (8), 2543-2549 Publication Date(Web): 27 March 2009 Downloadedfromhttp://pubs.acsorgonApril16,2009 Trp279 NTrp84 His440N More about this article Additional resources and features associated with this article are available within the html version Supporting Information Access to high resolution figures Links to articles and content related to this article Copyright permission to reproduce figures and/or text from this article View the full Text hTml ACS Publications High quality High impact Joumal of Medicinal Chemistry is published by the American Chemical Society 1155 Sixteenth Street N W, Washington, DC 20036Subscriber access provided by WEIZMANN INSTITUTE Journal of Medicinal Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Article The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(#)- nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad Aviv Paz, Qiong Xie, Harry M. Greenblatt, Wei Fu, Yun Tang, Israel Silman, Zhuibai Qiu, and Joel L. Sussman J. Med. Chem., 2009, 52 (8), 2543-2549• Publication Date (Web): 27 March 2009 Downloaded from http://pubs.acs.org on April 16, 2009 More About This Article Additional resources and features associated with this article are available within the HTML version: • Supporting Information • Access to high resolution figures • Links to articles and content related to this article • Copyright permission to reproduce figures and/or text from this article