Natural history of type 2 DM After the diagnosis of type 2 diabetes IR constantly exists Insulin secretion ability gradually declines: When FPG reachs the diagnostic criteria, insulin secretion ability has already declined by 50% When FPG≌7.0 mmoL,阝- insulin secretion ability When fPg≥10~11.0mmol/L,β- Insulin secretion ability has already neared absolute deficiencyNatural history of type 2 DM After the diagnosis of type 2 diabetes: IR constantly exists Insulin secretion ability gradually declines: When FPG reachs the diagnostic criteria，insulin secretion ability has already declined by 50% When FPG≥7.0mmol/L，-cell insulin secretion ability When FPG≥1011.0mmol/L，-C insulin secretion ability has already neared absolute deficiency