帕金森病的研究历程 Demonstration that the direct and Introduction of the direct and Demonstration of efficient indirect pathways are not indirect pathway model of the engraftment of,and motor deficit alternatively but concomitantly basal ganglia circuitry reversal by,dopaminergic neurons active to modulate motor function First double-blind controlled derived from human embryonic Deep brain trial of a cell-based therapy in PD stem cells in an animal model of PD Report suggests that the stimulation of the cell surface molecule subthalamic Mutations in Parkin-PINK1 First phase l LAG3 is a key factor in nucleus becomes SNCA identified as Multiplication reported to clinical trial for the initiation of effective for the Cu of SNCA found requlate immunotherapy a-synuclein cell-to-cell treatment of PD to cause PD mitophagy in PD transmission 1989199019951996 19971998 20012003200420082010 201120122013201420152016 Reversal of GBA mutation identified Direct gener atior monstration of experin ntal clinical trial of as a risk factor for PD n bthalamic glial cell-der First suggestion of iferential cell-to-cell transmissior nouse and eeding and nucleus actor for the of a-synuclein human fibroblasts pathology-inducing treatment of PD capacities Complex I deficit upport found in living animals for the detected in PD d-Synuclein found to be the alternatively active and thus opposite Potential role suggested brains main component of Lewy bodies actions(go versus no go)of the striatal for the microbiome in PD direct and indirect pathways Demonstration of the usefulness of simple asts.to screen for a sms of neurodegeneration Serge Przedborski,2017帕金森病的研究历程 Serge Przedborski, 2017