TISSUE ENGINEERING Problems with tissue engineering Most tissues cannot yet be produced by tissue engineering (ie, in vitro). Implantation of tissues produced in vitro may not remodel in vivo and may not become integrated with(bonded to) host tissue in the body. Solution Use of implants to facilitate formation regeneration) of tissue in vivo. Regenerative medicine Scaffold-based regenerative medicineTISSUE ENGINEERING TISSUE ENGINEERING Problems with Tissue Engineering Problems with Tissue Engineering • Most tissues cannot yet be produced by Most tissues cannot yet be produced by tissue engineering ( tissue engineering (i.e., in vitro in vitro). • Implantation of tissues produced Implantation of tissues produced in vitro in vitro may not remodel may not remodel in vivo in vivo and may not and may not become integrated with (bonded to) host become integrated with (bonded to) host tissue in the body. tissue in the body. Solution Solution • Use of implants to facilitate formation Use of implants to facilitate formation (regeneration) of tissue (regeneration) of tissue in vivo. in vivo. – “Regenerative Medicine” “Regenerative Medicine” – Scaffold Scaffold -based regenerative medicine based regenerative medicine