Bacteria and biofilm The diseases caused by bacteria is a problem in clinical therapy,because of the complicated formation and structure of bacterial biofilm and antibiotic resistance. 5 stages of Biofilm Development Biofilms are the product of a microbial I developmental process.The process is I summarized by five major stages of biofilm I development: I.Initial attachment ll.Irreversible attachment 3 IlI. Maturation I IV.Maturation ll iV.Dispersion Annual Review of Microbiology.2000,54:49-79.Bacteria and biofilm The diseases caused by bacteria is a problem in clinical therapy, because of the complicated formation and structure of bacterial biofilm and antibiotic resistance. Biofilms are the product of a microbial developmental process. The process is summarized by five major stages of biofilm development: I. Initial attachment II. Irreversible attachment III. Maturation I IV. Maturation II V. Dispersion Annual Review of Microbiology. 2000,54: 49–79