1. Enzymes were among the first biological macromolecules to be studied chemically 1.1 Much of the early history of biochemistry is the history of enzyme research. 1.1.1 Biological catalysts were first recognized in studying animal food digestion and sugar fermentation with yeast(brewing and wine making). 1.2 Ferments(i. e,, enzymes, meaning in “ in yeast”) were thought( wrongly)tobe separable from living yeast cells for quite some time (Louis Pasteur)1. Enzymes were among the first biological macromolecules to be studied chemically 1.1 Much of the early history of biochemistry is the history of enzyme research. 1.1.1 Biological catalysts were first recognized in studying animal food digestion and sugar fermentation with yeast (brewing and wine making). 1.1.2 Ferments (i.e., enzymes, meaning in “in yeast”) were thought (wrongly) to be inseparable from living yeast cells for quite some time (Louis Pasteur)