Fc受体介导的效应功能 FcR:Fcreceptor,结合抗体Fc段的受体 FCR功能多样，可发辉不同的生物学效应 Receptor FcyRI FcyRIl-A FcyRll-B2 FcyRll-B1 FeyRIll FcsRIl FcaRl (CD64 (CD32) (CD32 (CD32 (CD16 FcxRI (CD23) (CD89 Fcu/pR Structure ☐a72kDa a 40kDa a50-70k0a a 45 kDa a55-75k0a lectin trimer domain a 70kDa 33 kDa 9kDa y 9kDa 0 y-like OITIM domain ITIM Binding IgG1 IgG1 lgG1 lgG1 lgG1 IgE IgE IgA1.IgA2 IgA,IgM 10eM- 2×10M1 2×10的M-1 2×105M 5×105M-1 100M 2-7×10M1 107M1 3×102M1 Order of 1)IgG1=lgG3 )g6 263=gG2 1)g61=gG3 2106 1lgG1=g6的 IgG1-lgG3 IgA1-lgA2 affinity 股 2-7×108M1 搬 3)lgG4 3)gG2 (monomer) Cell type Macrophages Macrophages Macrophages B cells NK cells Mast cells Eosinophils Macrophages Macrophages Neutrophils Neutrophils Neutrophils Mast cells Eosinophils Basophils B cells Eosinophilst B cells Eosinophils Eosinophils Eosinophils Macrophages Neutrophils Platelets Neutrophils Langerhans Mast cells cellsFc受体介导的效应功能 FcR：Fc receptor，结合抗体Fc段的受体 FcR功能多样，可发挥不同的生物学效应