Stopping treatment bone age of greater than 14 yr in girl and greater that 16 yr in boys. Replacement should also be directed at other hormonal deficiencies TSH deficient subiects: L-T4 ACTH deficient patients: hydrocortisone Gonadotropins deficient patients gonadal steroids• Stopping treatment : bone age of greater than 14 yr in girl and greater that 16 yr in boys. Replacement should also be directed at other hormonal deficiencies • TSH deficient subjects: L-T4 • ACTH deficient patients: hydrocortisone • Gonadotropins deficient patients: gonaddal steroids