Week 1 Quiz 1 Pathology Cell Injury Two days ago,you stubbed your big toe while hurrying to the gym. Now there is an ecchymosis unde r the nail bed as shown above.Which of the following cytologic features is associated with this reversible cell injury? A.Apoptosis B.Liquefactive necrosis C.Lysosome rupture D.Nuclear pyknosis E.Swelling of the mitochondria Ans:E ired leading to accumulation of intracellular scecellular volne resomssottase grad ions.The s with the mito drial me control.lea death: h ng to swelling.Apoptosis is th is process 1. process of enzymatic degradation and protein denaturation in the brain in reaction to exogenous injury (infarct or infection).Lysosome rupture and nuclear pyknosis are cellular changes of necrosis that occur in reaction to irreversible cell iniury. 2.A 16 year-old boy sustained blunt trauma to the abdomen when the vehicle he was driving struck a bridge abutment at high speed.Peritoneal lavage(washing the peritoneal cavity with saline)showed a hemoperitoneum(blood in the abdominal cavity),and at laparotomy(surgical exploration of the abdomen),a small portion of the left lobe of the liver was removed because of -1 - 1 - Week 1 Quiz 1 Pathology Cell Injury 1. Two days ago, you stubbed your big toe while hurrying to the gym. Now there is an ecchymosis under the nail bed as shown above. Which of the following cytologic features is associated with this reversible cell injury? A. Apoptosis B. Liquefactive necrosis C. Lysosome rupture D. Nuclear pyknosis E. Swelling of the mitochondria Ans: E In acute injury, cellular volume regulation is impaired leading to accumulation of intracellular sodium and other ions. The disruption of the cell’s voltage gradient interferes with the mitochondrial volume control, leading to swelling. Apoptosis is the process of programmed cell death; this process is not activated by traumatic injury. Liquefactive necrosis is an inflammatory process of enzymatic degradation and protein denaturation in the brain in reaction to exogenous injury (infarct or infection). Lysosome rupture and nuclear pyknosis are cellular changes of necrosis that occur in reaction to irreversible cell injury. 2. A 16 year-old boy sustained blunt trauma to the abdomen when the vehicle he was driving struck a bridge abutment at high speed. Peritoneal lavage (washing the peritoneal cavity with saline) showed a hemoperitoneum (blood in the abdominal cavity), and at laparotomy (surgical exploration of the abdomen), a small portion of the left lobe of the liver was removed because of