Hypercoagulable states Secondary (acquired) High risk Prolonged bed rest or immobilization. Myocardial infarction. Tissue damage (Surgery, fractures, burns). Cardiac failure. Cancer. Acute leukemia. DIC Myoproliferative disorders. Prosthetic cardiac valves. Homocystinuria Thrombotic thrombocytopenia.Hypercoagulable states Secondary (acquired): High risk: Prolonged bed rest or immobilization. Myocardial infarction. Tissue damage (surgery, fractures, burns). Cardiac failure. Cancer. Acute leukemia. DIC. Myoproliferative disorders. Prosthetic cardiac valves. Homocystinuria. Thrombotic thrombocytopenia