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杨海燕etal 神经胶质瘤多组学研究进展 of brain tumor patients using direct-tissue outcome in malignant glioma independent natrix-assisted laser desorption ionization of MgmT promoter methylation. Plos One mass spectrometry. Cancer Res 2005 65(17):76747681 46 Castelo-Branco P Choufani s. mack S 39. Brennan C, Momota H, Hambardzumyan D Gallagher D, Zhang C, Lipman T, Zhukova Ozawa t Tandon a pedraza a. holland e N. Walker Ej. Martin D. Merino. et al. Glioblastoma subclasses can be defined by Methylation of the TERT promoter and risk activity among signal transduction pathways stratification of childhood brain tumours an and associated genomic alterations. Plos ntegrative genomic and molecular study One2009,4(11):7752 Lancet oncol2013,14(6):534542 40. Choi JD, Lee Js. Interplay between 47. Ying Z, Li Y, Wu J, Zhu X, Yang Y, Tian H, Li Epigenetics and Genetics in Cancer W, Hu B, Cheng SY, Li M. Loss of miR-204 Genomics Informatics 2013, 11(4): 164-173 expression enhances glioma migration and 41. You JS, Jones PA. Cancer genetics and stem cell-like phenotype. Cancer Res 2013, epigenetics: two sides of the same coin? 73(2):990-999 Cancer cel2012,22(1):9-20 48. Podlevsky JD, Chen JJ. Evolutionary 42. Liao P. strom Qt. Stetson L, barnholtz perspectives of telomerase RNA structur Sloan JS. Models of Epigenetic Age and function. RNA Biol 2016, 13(8): 720-732 Capture Patterns of DNA Methylation in 49. Wang Y, Zhou Z, Luo H, Wu Z, Geng J, Miu W Glioma Associated with Molecular Subtype, Pu Y, Liu N, You Y, Yang Z Combination of Survival and recurrence. Neuro-oncol tamoxifen and antisense human telomerase 2018.Feb8. RNA inhibits glioma cell proliferation 43. Silber jR. Bobola Ms. blank A. Chamberlain and anti-apoptosis via suppression o MC.o(6)-methy guanine-DNA telomerase activity. Mol Med Rep 2010 methyltransferase in glioma therapy 3(6):935-940 promise and problems. Biochimica 50 Sampl S, Pramhas S, Stern C, Preusser Biophysica Acta 2012, 1826(1): 71-82 M, Marosi C, Holzmann K. Expression of 44 Quintavalle C, Mangani D, Roscigno G telomeres in astrocytoma WHo grade 2 to Romano G, Diaz-Lagares A, laboni M 4: TERRA level correlates with telomere Donnarumma e. fiore d. De marinis P length, telomerase activity, and advanced Soini Y, et al. MiR-221/222 target the DNA clinical grade. Translational Oncol 2012 methyltransferase MGMT in glioma cells 5(1):56-65 Plos one2013,8(9):74466 51. Shi Y, Wang Y, Luan W, Wang P, Tao T, 5 Kreth S, thon N, Eigenbrod s, lutz J Zhang J, Qian J, Liu N, You Y. Long non Ledderose C, Egensperger R, Tonn JC coding RNA H19 promotes glioma cell Kretzschmar HA. hinske LC, Kreth Fw. invasion by deriving miR-675. Plos One O-methylguanine-DNA methyltransferase 2014,9(1):86295 (MGMT) MRNA expression predicts MRF2018;2(1)2;Do:10.12208imrf20180002 收稿日期201808-26出刊 8-09-10杨海燕 et al. 神经胶质瘤多组学研究进展 IMRF 2018; 2:(1)2; DOI:10.12208/j.imrf.20180002 15 收稿日期 2018-08-26 出刊日期 2018-09-10 of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry. Cancer Res 2005, 65(17): 7674-7681. 39.Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PloS One 2009, 4(11): 7752. 40.Choi JD, Lee JS. Interplay between Epigenetics and Genetics in Cancer. Genomics Informatics 2013, 11(4): 164-173. 41.You JS, Jones PA. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 2012, 22(1): 9-20. 42.Liao P, Ostrom QT, Stetson L, Barnholtz￾Sloan JS. Models of Epigenetic Age Capture Patterns of DNA Methylation in Glioma Associated with Molecular Subtype, Survival, and Recurrence. Neuro-Oncol 2018. Feb 8. 43.Silber JR, Bobola MS, Blank A, Chamberlain M C . O ( 6 ) - m e t h y l g u a n i n e - D N A methyltransferase in glioma therapy: promise and problems. Biochimica Biophysica Acta 2012, 1826(1): 71-82. 44.Quintavalle C, Mangani D, Roscigno G, Romano G, Diaz-Lagares A, Iaboni M, Donnarumma E, Fiore D, De Marinis P, Soini Y, et al. MiR-221/222 target the DNA methyltransferase MGMT in glioma cells. PloS One 2013, 8(9): 74466. 45.Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW. O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. PloS One 2011, 6(2): 17156. 46.Castelo-Branco P, Choufani S, Mack S, Gallagher D, Zhang C, Lipman T, Zhukova N, Walker EJ, Martin D, Merino D, et al. Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol 2013, 14(6): 534-542. 47.Ying Z, Li Y, Wu J, Zhu X, Yang Y, Tian H, Li W, Hu B, Cheng SY, Li M. Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res 2013, 73(2): 990-999. 48.Podlevsky JD, Chen JJ. Evolutionary perspectives of telomerase RNA structure and function. RNA Biol 2016, 13(8): 720-732. 49.Wang Y, Zhou Z, Luo H, Wu Z, Geng J, Miu W, Pu Y, Liu N, You Y, Yang Z. Combination of tamoxifen and antisense human telomerase RNA inhibits glioma cell proliferation and anti-apoptosis via suppression of telomerase activity. Mol Med Rep 2010, 3(6): 935-940. 50.Sampl S, Pramhas S, Stern C, Preusser M, Marosi C, Holzmann K. Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade. Translational Oncol 2012, 5(1): 56-65. 51.Shi Y, Wang Y, Luan W, Wang P, Tao T, Zhang J, Qian J, Liu N, You Y. Long non￾coding RNA H19 promotes glioma cell invasion by deriving miR-675. PloS One 2014, 9(1): 86295
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