(B) Solid support 23456 Barrel Extracting phase Septum piercing needle Fiber attachment tubing mple Coated fuse 雷国 Stirring bar Fig. L. Design of the commercial SPMe device (A and B) and the experimental procedure of fiber SPMe(C):(1) spme devi sample vial; (2) introduction of septurm-piercing needle of the SPMe device into the sample vial; ( direct immersion of the fibe the sample solution; (4)extraction of analytes to the fiber; (5) moving the fiber back into the needle; (6) detachment of the SPME ber into from the sample vial