176 核技术 第30卷 在正常乳腺组织和良性乳腺肿瘤组织中的含量基本 Nucl Tech,2006,29(9)641-645 相等,而在癌变组织中稍有下降。恶性肿瘤中的Fe Huang Y Y, Lu J X, HeR G et al. Nucl Instrum Methods 和zn是正相关性,在良性肿瘤中是负相关性。因 Phys res a2001,467468:1301-1304 此,不同组织的特异性能够准确地反映出肿瘤癌变10张军初,傅尚希,蔡清萍,等.第二军医大学学报 的程度,为乳腺肿瘤的诊断提供很好的辅助作用。 2003,24(1):80-82 参考文献 ZHANG Junchu, FU Shangxi, CAI Qingping, et aL. Acad J Sec Mil Med Univ, 2003, 24(1): 80-82 I Bothorel S, Meunier BB, Muller S A. Int J Intell Syst, 11 Huang Y L, Shen J Y, Lin T H. Clin Biochem, 1999, 32(2) 1997,12:819848 131-136 2林玉斌实用放射学杂志,2003,19(4):356-358 12 Wynder E L, Reddy B S, Weiburger J H, et al. Cancer, LIN Yubin. J Pract Radiol, 2003, 19(4): 356-358 1992,70(5 Suppl):1222-1228 Liu CL Zhang Y, Zhang Y, et al. Med Sci Monit. 200 13何群,马汝海,李延宾,等.光谱学与光谱分析,2000 11(5):Mr3-38 204):540541 4 Liu Chenglin, Yan Xiaohui, Zhang Xinyi, et al Phys Med HE Qun, MA Ruhai, LI Yanbin, et al. Spec and Spec Anal Biol,2007,52(2):419427 2000204):540-541 5 Giammarile F, Bremond A Nucl Instrum Methods Phys 14 Weinstein R E, Bond B H, Silberberg B K, et al. Cancer, ResA,2004,527:83-86 1982,5011)24062409 6 Liu C L, Zhang Y, Yan x H, et al. J Lumin, 2006 15 Gonchara A, Kolmogorov Yu, Dikalova A, et al. Nuc 119-120:132-136 Instrum Methods Phys Res A, 2001, 470: 405-408 7 Huang Y Y, Wu Y R, Zhao L M, et al. Spectrochimica16李琼,张卫华.实用预防医学,200,1205:134-1135 Acta B,2001,56:2057—2062 LI Qiong, ZHANG Weihua. Prac Pre Med, 2005, 12(5) 8董元兴,高愈希,陈春英,等.核技术,2006,299):641 11341135 DONG Yuanxing, GAO Yuxi, CHEN Chunying, ef al. Analysis of trace elements in breast tumor tissues LIU Chenglin 2 YAN Xiaohui zHANG Xinyi YANG Wentao SHI Daren HUANG YuyingHE Wei* 1( Synchrotron Radiation Research Center, Surface Physics(National Key) Laboratory of Fudan Universit Shanghai 200433, China 2( Physics Department of Yancheng Teachers'College, Yancheng 224002, China 3( Cancer Hospital, Medical Center of Fudan University, Shanghai 200032, China) 4( Beiing Synchrotron Radiation Facility, Institute of High Energy Physics, the Chinese Academy of Sciences, Beijing 100049, China) Abstract The variation of relative contents of some typical trace elements in normal breast tissues, benign breast tumor tissues and breast cancer tissues is studied by the synchrotron radiation X-ray fluorescence(SR-XRF technique. According to the results of SR-XRF, there exist the same kinds of trace elements in various breast tissues, but their relative contents are different. The differences for Ca, Fe and Zn are obvious between normal and b tumor tissues. Comparing the contents of elements in breast tumor tissues with normal ones, s, Cr, Mn, Ni, Cu and Se are found to be of positive correlation, i.e. their contents in tumor tissues are increased; but K and Ca are of negative correlation. The contents of P in normal breast tissues are the same as in benign tissues, but a little decreasing in malignant ones. However, such correlation is positive for Fe and Zn in cancerous tissues, and negative in benign tissues. The above differences might be used to characterize changes that take place as breast tissues become diseased. Key words Trace elements, Breast tissues, X-ray fluorescence analysis, Synchrotron radiation CLC04334,R737.9