Pathophysiology o Allergic reaction is an exaggerated or inappropriate immune reaction and causes damage to the host Type I immediate hypersensitivity reaction mediated by IgE antibodies which trigger the mast cells and basophils to release pharmacologically active agentsPathophysiology ⚫ Allergic reaction is an exaggerated or inappropriate immune reaction and causes damage to the host ⚫ Type I immediate hypersensitivity reaction mediated by IgE antibodies, which trigger the mast cells and basophils to release pharmacologically active agents