Drosophila C elegans 果蝇与线虫病毒入 RNA Virus RNA Virus miRNA 侵诱导产生的 dsRNA SiRNA RDE4 1st=国R AAA AAA (A)The Drosophila pathway is conceptually 60s @ Armi similar to a linear antiviral silencing Pathway in plants (B) Antiviral silencing in C elegans has been AAA AAA AAA inferred through studies of artificial infection systems. ALG, RDE-1, and SAGO are worm Translational repression? Degradation AGOs that recruit miRNAs, 1st siRNAs, and 2nd siRNAs, respectively. RRF-1 is thought to 注:红色代表病毒产生可抑制 produce 2nd siRNAs or to copy RNAS CRNAs) 宿主细胞抗病毒机制的成 2nd cRNA directly from RDE3-stabilized templates. SID-1 分 SAGO-1 may possibly take up viral dsRNAs into cells These pathways can be disrupted at multiple AAA points by endogenous suppressors(red) cel130413-426,2007 De gradation ?果蝇与线虫病毒入 侵诱导产生的 siRNA (A) The Drosophila pathway is conceptually similar to a linear antiviral silencing Pathway in plants. (B) Antiviral silencing in C. elegans has been inferred through studies of artificial infection systems. ALG, RDE-1, and SAGO are worm AGOs that recruit miRNAs, 1st siRNAs, and 2nd siRNAs, respectively. RRF-1 is thought to produce 2nd siRNAs or to copy RNAs (cRNAs) directly from RDE3-stabilized templates. SID-1 may possibly take up viral dsRNAs into cells. These pathways can be disrupted at multiple points by endogenous suppressors (red). Cell, 130:413-426, 2007