CORTISONE PREPARATIONS Cortisone is primarily used as its 21-acetate Other 21-ester derivatives available because of increased stability and longer include duration of action OR CH3 HO OH OH CO Oral or intramuscular dose usually Hydrocortisone cypionate R 25 mg 4 times daily Topically 1 to 2.5% lotion Hydrocortamate sodium succinate R=Nat OOCCH2 CH2CO-(water soluble) Intraveinous emergency treatmentCORTISONE PREPARATIONS Cortisone is primarily used as its 21-acetate because of increased stability and longer duration of action O O O O OH CH3 O Other 21-ester derivatives available include: O O HO OH OR CO Hydrocortisone cypionate R = Hydrocortamate sodium succinate R = Na+ -OOCCH2CH2CO- (water soluble) Intraveinous emergency treatment Oral or intramuscular dose usually 25 mg 4 times daily Topically 1 to 2.5% lotion