Genetic alterations leading to Constitutive Activation of rtks Deletion of extracellular domain Mutations that stimulate dimerization without ligand binding Mutations of Kinase domain Overexpression of ligand Overexpression of receptorGenetic alterations leading to Constitutive Activation of RTKs • Deletion of extracellular domain • Mutations that stimulate dimerization without ligand binding • Mutations of Kinase domain •Overexpression of Ligand •Overexpression of Receptor