河北医科大学药学院2018 A well-known dispute about the Structure of Penicillin Structure of Penicillin Cn告诉罗氏 天然药物化学教研室史清文教授 2 河北医科大学药学院2018 天然药物化学教研室史清文教授 2 83 C C O NH N S H H H COOH H H O This incident is significant because Robinson refused to give much credence to spectroscopic data, while Woodward was a pioneer in using it for organic structure determination. It displays the generational gap between two of the greatest synthetic organic chemists of the twentieth century. A well-known dispute about the Structure of Penicillin 84 C C O NH N S H H H COOH H H O Penicillin G was proposed by Woodward in 1944 to contain a novel b￾lactam in its structure based on degradation products, reaction profiles, and UV studies. 二战时期，英、美两国合作青霉素计划，化学组由R. Robinson 领导。 但他的结构与伍德沃德的不同。伍德沃德的内酰胺(b-lactam)结构由钱恩 (E. Chain)告诉罗氏，而后者老羞成怒，将桌上墨水瓶向钱恩掷去，幸未 击中。青霉素的分子式，经X光晶体衍射求正，正如伍德沃德所想的一样。 Structure of Penicillin