Reagents for Elimination Br Br CH3一CH-CH-CH2-CH KOH(fused) CH3一C≡C-CH2一CH3 200°C Molten KOH or alcoholic KOH at 200C favors an internal alkyne. Sodium amide,NaNHz,at 150C,followed by water,favors a terminal alkyne. 1)NaNH2,150°C CH一CH2一CH2一CHC2 CH一CH2一C=CH 2)H20 Reagents for Elimination ◼Molten KOH or alcoholic KOH at 200C favors an internal alkyne. ◼Sodium amide, NaNH2 , at 150C, followed by water, favors a terminal alkyne. CH3 C C CH2 CH3 200°C KOH (fused) CH3 CH CH CH2 CH3 Br Br , 150°C CH3 CH2 C CH 2) H2O 1) NaNH2 CH3 CH2 CH2 CHCl2