上泽充通大￥ Shanghai Jiao Tong University Heat sterilization is the most widely used method of controlling microbial growth High temperatures denature macromolecules Some bacteria produce resistant cells called endospores Can survive heat that would rapidly kill vegetative cells Shanghai Jiao Tong UniversityShanghai Jiao Tong University Heat sterilization is the most widely used method of controlling microbial growth • High temperatures denature macromolecules Some bacteria produce resistant cells called endospores • Can survive heat that would rapidly kill vegetative cells