25 Clinical features The clinical features of Ch are highly variable O Most common overt symptoms: Fatigue, Loss of appetite, and Bouts of mild jaundice. o Physical findings: Hepatomegaly with hepatic tenderness, and mild splenomegaly. o Laboratory examination: Persistent elevation falt & ast o Extrahepatic injure vasculitis, arthritis ote:ALT: alanine aminotransferase,丙氨酸转氨酶 AST: aspartate aminotransferase.,天冬氨酸转氨酶Clinical features: The clinical features of CH are highly variable. ⚫ Most common overt symptoms: Fatigue, Loss of appetite, and Bouts of mild jaundice. ⚫ Physical findings: Hepatomegaly with hepatic tenderness, and Mild splenomegaly. ⚫ Laboratory examination: Persistent elevation of ALT & AST ⚫ Extrahepatic injure : vasculitis, arthritis, ---- Note: ALT: alanine aminotransferase, 丙氨酸转氨酶; AST : aspartate aminotransferase, 天冬氨酸转氨酶. 25