Immunogenetics Increased Risk for SLE in: HLA-DR2 (anti-DNA Abs) HLA-DR3(anti-Ro Abs) Null alleles at c2 and C4 loci SLE may be transmitted in an autosomal dominant pattern(family studies)Immunogenetics Increased Risk for SLE in: • HLA-DR2 (anti-DNA Abs) • HLA-DR3 (anti-Ro Abs) • Null alleles at C2 and C4 loci • SLE may be transmitted in an autosomal dominant pattern (family studies)