天然产物化学促进分析化学的发展 器 天然产物化学诺贝尔奖候选人 The Ginkgo Tree's Chemical Charms 980 Wanderine Natural produets chemist-Nakanishi koi tture determination of Ginkgolide 100 MHz 1966 What Can Organic Chemist Do With NP? First Bio-mimie Synthesis c-- metic total synthesis of (Robinson,1917) 1g,2m. 1 Dorothy Crowfoot Hodgkin 因用X射线衍射方法研究青霉素 和维生素B12等的分子结构成功， 英国科学家霍奇金在1964年获得 诺贝尔化学奖。 天然产物化学促进分析化学的发展 Richard R. Ernst (瑞士)因发明了 傅立叶变换核磁共振分光法和二维 核磁共振技术在1991年获得诺贝尔 化学奖 。 Dorothy C. Hodgkin—— 霍奇金中国人民的老朋友 2005-7-1《细胞》 唐有祺院士 饶子和 院士 廖鸿英 天然产物化学诺贝尔奖候选人 IR, CD,NOE, NMR 800 papers, 9 books 达纳康 550 Students (Tanakan®) O O O O O O O O O O O CH3 O HO CH3 CH3 CH3 CH3 H3C CH3 H H H H H H H H H H H H H H H H O OH HO HO CH3 O CH3 OH OH O O O O HO O O HO O OH H OH H H A Wandering Natural Products Chemist A Wandering Natural Products Chemist-Nakanishi Koji Nakanishi Koji A Master of Chemistry and Magic 秦国伟 ACS MEETING NEWS The Ginkgo Tree's Chemical Charms The Ginkgo Tree's Chemical Charms Aesthetically pleasing and medically useful, ginkgolides Aesthetically pleasing and medically useful, ginkgolides fascinate Koji Nakanishi “We followed the bitter taste with our tongues” Bilobalide O O O O O O OH HO 最早的生物活 性指导分离： Structure Determination of Structure Determination of Ginkgolide 100 MHz 1966 Biomimetic total synthesis of tropinone (Robinson, 1917) (1) Robinson, R. J. Chem. Soc., Trans. 1917, 762. (2) Robinson, R. J. Chem. Soc., Trans. 1917, 762. (3) See also: Birch,A. J. Notes Records Royal Soc. London 1993, 47, 277. First Bio-mimic Synthesis mimic Synthesis 1886-1975 1947年Nobel Prize R. Robinson CHO CHO + H2NMe + COOH COOH O Aqua N O Me What Can Organic Chemist Do With NP? What Can Organic Chemist Do With NP?