Antiarrhythmic Therapy Empiric Pathophysiologic Arrhythmia Diagnosis Arrhythmia Diagnosis Known or suspected mechanisms BLACK BOX Critical components Vulnerable parameters Targeted subcellular units Interventions Interventions Clinical Outcomes Clinical OutcomesAntiarrhythmic Therapy Empiric Arrhythmia Diagnosis Interventions Clinical Outcomes Interventions Clinical Outcomes Pathophysiologic Arrhythmia Diagnosis Known or suspected mechanisms Critical components Vulnerable parameters Targeted subcellular units BLACK BOX