through the plasma membrane and to reach the nucleus And some cytosolic proteins may move to extracellular space, e.g. calmodulin, annexin Il etc s The protein transports are very complex and multisteps process. there are a series of other cofactors or associated proteins that are involved in different steps of these processes. Their different roles will be discussed respectivelythrough the plasma membrane and to reach the nucleus. And some cytosolic proteins may move to extracellular space, e.g. calmodulin, annexin II etc.. * The protein transports are very complex and multisteps process, there are a series of other cofactors or associated proteins that are involved in different steps of these processes. Their different roles will be discussed respectively