维普资讯htp:/www.cqvip.com 第4期 杨雨辉等;几种氟硅诺酮类药物对嘈水气单胞菌体外药效学研究 435 Pharmacodynamics of several fluoroquinolones against A. hydrophila in vitro YANG Li-hui, TONG Heng-min, LU Tong-yan, ZHAO Ji-wei, LIU Hong-bai, MA L (1. Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin Heilongjiang 150070, PRC 2. Northeast Agricultural University Harbin Heilongjiang 150030 PRC) Abstract: The MIC and MBC of Ciprofloxacin hydrochloride, ciprofioxacin lactate, Enrofloxacin Danofloxacin and Difloxacin were estimated in the paper. Their MIC is 0. 00626,0.00625,0.0125,0 05 0.2 ug. mL-I, respectively. Their MBC is 0. 025,0.025,0 05,0.1,0.8 Hg.-,respectively. The law of the Fluoroquinolones against A hydrophila i o shows that the difference is significant between 2 MIC and 5 MIC, isn't significant between 5 MIC and 8 MIC. There are different character of killing A hydro phila in the different Fluoroquinolones Key words: fluoroquinolones; A hydrophila; pharmacodynamics 作者简介:杨雨辉(1971一),男,黑龙江人,现为中国水产科学研究院黑龙江省水产研究所助理研究员 东北农业大学动医学院在读博士生。第 4期 杨雨辉 等 ；几种 氟硅诺 酮类 药物对 嗜水 气单 胞菌体 外 药效 学研 究 ·435· Pharm acodynam ics of severalflu0r0quin0l0nes againstA．hydrophila in vit YANG Li—hui，TONG Heng—rain，LU Tong—yan，ZHAO ji—wei LIU Hong—bai．M A Li (1．HeilongiiangRiverFisheriesResearch Institute，ChineseAcademyofFisherySciences，HarbinHeilongiiang150070，PRC 2．NortheastAgriculturalUniversityHarbinHeilongjiang150030PRC) Abstract：The M IC and M BC of Ciprofloxacin hydrochloride，ciprofioxacin lactate，Enrofloxacin， Danofloxacin and Difloxacin were estim ated in the paper．TheirM IC iS 0。00626，0。00625，0．0125，0．05， 0．2 lag ·m L一1，respectively。Their M BC is 0。025，0．025，0．05，0．1，0．8 lag ·mL一 ，respectively．The law ofthe Flu0r0auin0l0nes againstA ．hydrophila in vitroshows thatthe difference is significant between 2 M IC and 5 M IC ．isn’tsignificant between 5 M IC and 8 M IC．There are differentcharacter of killing A 。 hydrophilain the differentFlu0r0quin0l0nes． Key words：flu0r0quin0l0nes；A。hydrophila；pharm acodynam ics 作 者简介 ：杨 雨辉 (1971一)，男 ，黑龙 江人 ，现 为中 国水 产科学研 究院 黑龙 江 省水产 研究 所助理 研究 员 ， 东北农业大学动 医学院 在读博士生 。 维普资讯 http://www.cqvip.com