国生一 国上人生 New types of nebulizer Dry powder inhaler(DPI)is an active research area because .HaloLite adaptive aerosol delivery system Automatic coordination between dose delivery and inhalation Omron MicroAir NE-U22 ·No propellants Respimat Soft MistTM Inhaler Potential drug stability advantages High dose carrying capacity 图上生一 Dry Powder Inhalers 国生 ④Powder .Low aerodynamic diameters ©Devices ·Small physical size .Low particle density(e.g porous particles) Pre-metered single dose Shape (e.g.,elongated particles) Rough surface (to increase air drag force) Pre-metered multidose as single units Low inter-particulate forces Rough surface(to reduce particle interaction) Multidose bulk reservoir Surface composition(to reduce surface energy) Low bulk density (loose particle packing to reduce particle contacts) Using fine carriers 国生 Learning objectives Category of inhalation dosage forms Concept:propellant,cold filling,pressure filling Mechanisms of particle deposition in respiratory tract 77 Shanghai Jiao Tong University New types of nebulizer • HaloLite adaptive aerosol delivery system • Omron MicroAir NE-U22 • Respimat Soft MistTM Inhaler Shanghai Jiao Tong University Dry powder inhaler (DPI) is an active research area because • Automatic coordination between dose delivery and inhalation • No propellants • Potential drug stability advantages • High dose carrying capacity Shanghai Jiao Tong University Dry Powder Inhalers Powder • Low aerodynamic diameters • Small physical size • Low particle density (e.g., porous particles) • Shape (e.g., elongated particles) • Rough surface (to increase air drag force) • Low inter-particulate forces • Rough surface (to reduce particle interaction) • Surface composition (to reduce surface energy) • Low bulk density (loose particle packing to reduce particle contacts) • Using fine carriers Shanghai Jiao Tong University Devices • Pre-metered single dose • Pre-metered multidose as single units • Multidose bulk reservoir Shanghai Jiao Tong University Learning objectives Category of inhalation dosage forms Concept: propellant, cold filling, pressure filling Mechanisms of particle deposition in respiratory tract