Aldosterone antagonist Spironolactone Aldosterone antagonist,K-sparing diuretic Prevention of aldosterone effects on: Kidney Heart? Aldosterone inappropriately elevated in CHF Mobilizes edema fluid in heart failure Prevention of hypokalemia induced by loop diuretics (protection against digitalis toxicity?) Prolongs life in CHF patientsAldosterone Aldosterone antagonist antagonist  Aldosterone antagonist, K-sparing diuretic  Prevention of aldosterone effects on: – Kidney – Heart?  Aldosterone inappropriately elevated in CHF  Mobilizes edema fluid in heart failure  Prevention of hypokalemia induced by loop diuretics (protection against digitalis toxicity?)  Prolongs life in CHF patients Spironolactone Spironolactone