Spectrum of Systems Biology detailed models-describe rates concentrations structure low-resolution models-describe information flow, logic, mechanism circuitry logic/controI-positive and negative regulation connectivity/topology-who talks to who? interaction scaffold parts list- protein and DNA sequences( structures) Recommended reading: Ideker Lauffenburger, TRENDS in Biotechnology(2003)21, 255-262Spectrum of Systems Biology detailed models - describe rates, concentrations, structure low-resolution models - describe information flow, logic, mechanism circuitry logic/control - positive and negative regulation connectivity/topology - who talks to who? interaction scaffold parts list - protein and DNA sequences (& structures) Recommended reading: Ideker & Lauffenburger, TRENDS in Biotechnology (2003) 21, 255-262