国生 国生 ©Preparation of MDI ©Pressure filling ·Pressure filling The product concentrate is quantitatively placed in the aerosol container.This method is used for ·Cold filling most Pharmaceutical formulations(aerosols) Advantages: Avoid moisture contamination Reduce lost of propellant 国丝生一 图上生 ④Cold filling ©Evaluation of MDI The product concentrate the propellant must be Emitted dose cooled Disadvantage:Aqueous systems cannot be filled, water turns to ice at this low temp. Particle sizing 国上人烤 neae 圈生 Active research area because Dry powder inhalers(DPIs) .Automatic coordination between dose delivery and inhalation ·No propellants Potential drug stability advantages High dose carrying capacity 66 Shanghai Jiao Tong University Preparation of MDI • Pressure filling • Cold filling Shanghai Jiao Tong University Pressure filling • The product concentrate is quantitatively placed in the aerosol container. This method is used for most Pharmaceutical formulations (aerosols) • Advantages: • Avoid moisture contamination • Reduce lost of propellant Shanghai Jiao Tong University Cold filling • The product concentrate & the propellant must be cooled • Disadvantage: Aqueous systems cannot be filled, water turns to ice at this low temp. Shanghai Jiao Tong University Evaluation of MDI • Emitted dose • Particle sizing Dry powder inhalers (DPIs) Shanghai Jiao Tong University Active research area because • Automatic coordination between dose delivery and inhalation • No propellants • Potential drug stability advantages • High dose carrying capacity