BIOSYNTHESIS OF GLUCOCORTICOIDS HO OH HO holesterol 17a-hydroxy 11B, 17a(oH)2-progesterone pregnenolone e b OH HOCH2 o HOCH2 O OH OH Ho OH c d HO pregnenolone 17a-hydroxy 11-deoxycortisol 0 Cortisol b. 17a-hydroxylase progesterone e OH 5ene-3β- hydroxy dehydrogenase o C, d d. 3-0X0-45-isomerase OH HOCH2 -O e. 21-hydroxylase OH f. 11B-hydroxylase HO 17x,21(0H)2 pregnenolone CortisoneBIOSYNTHESIS OF GLUCOCORTICOIDS HO HO O HO O OH O O OH O HOCH2 O OH O HOCH2 O HO OH O HOCH2 O O OH O O HO OH cholesterol pregnenolone 17a-hydroxy￾pregnenolone 17a-hydroxy￾progesterone 11-deoxycortisol Cortisol Cortisone 17a,21(OH)2 - pregnenolone 11b,17a(OH)2 -progesterone OH HO OH O b c,d e f e c,d f e b. 17a-hydroxylase c. 5-ene-3b-hydroxy dehydrogenase d. 3-oxo-4,5-isomerase e. 21-hydroxylase f. 11b-hydroxylase