X Table of Contents Jan Antosiewicz,Elibieta Btachut-Okrasinska,Tomasz Grycuk, James M.Briggs,Stanistaw T.Wtodek,Bogdan Lesyng,J.Andrew McCammon Exploiting Tsallis Statistics... 197 John E.Straub,Joan Andricioaei New Techniques for the Construction of Residue Potentials for Protein Folding.………· …212 Arnold Neumaier,Stefan Dallwig,Waltraud Huyer,Hermann Schichl III Enhanced Time-Stepping Algorithms Some Failures and Successes of Long-Timestep Approaches to Biomolecular Simulations........................................227 Tamar Schlick Application of a Stochastic Path Integral Approach to the Computa- tions of an Optimal Path and Ensembles of Trajectories.............263 Ron Elber,Benoit Roux,Roberto Olender On Some Difficulties in Integrating Highly Oscillatory Hamiltonian Sys- tems..........................................................281 Uri M.Ascher,Sebastian Reich Molecular Dynamics in Systems with Multiple Time Scales:Reference System Propagator Algorithms........... 297 Bruce J.Berne The Five Femtosecond Time Step Barrier ......... :.,318 Robert D.Skeel,Jesis A.Izaguirre Long Time Step MD Simulations Using Split Integration Symplectic Method.……332 Dusanka Janezic,Franci Merzel Comparison of Geometric Integrators for Rigid Body Simulation......349 Benedict J.Leimkuhler IV Quantum-Classical Simulations New Methods in Quantum Molecular Dynamics of Large Polyatomic Systems.........365 Pavel Jungwirth,R.Benny Gerber