When to use extraction? Distillation is preferential When distillation is dificult(azeotropic or relative volatility is close to 1) When distillation is inefficient(eg 1% HAc water) When the component is heat sensitive(eg bioproduct, penicillinWhen to use extraction? • Distillation is preferential. • When distillation is difficult (azeotropic or relative volatility is close to 1) • When distillation is inefficient (eg 1% HAc water) • When the component is heat sensitive (eg bioproduct, penicillin)